More and more people want to achieve the goal of becoming healthier. That health goal doesn?t just mean having a healthy body, but also a healthy mind. There are opportunities everywhere where one can achieve an inner peace while exercising to create a better mind -body connection. The Bronx section of New York City is no exception. If you live in the Bronx, you will find plenty of fitness studios with qualified yoga and pilates instructors to help you achieve your healthy goals.
Bronx Pilates is one of several classes that is offered here. Pilates itself, named after its German developer Joseph Pilates, is a system of physical fitness and body conditioning that involves stretching and flexibility. These exercises were devised with the goal of strengthening the mind as the body is strengthened. Many have found Pilates to be a refreshing and revitalizing work out utilizing this mind/body type of routine. A variety of Bronx pilates classes are offered, including the super pilates cardio boot camp.
In addition to pilates offerings in the Bronx, other great work out and conditioning classes are available in the Bronx, yoga Bronx is another favorite. Yoga, like Pilates, combines physical and mental strength, but also adds the additional element of spiritual discipline. Yoga is an ancient Hindu practice. Its main goal is to bring about a condition of spiritual enlightenment while meditating, and involves certain positions that are intended to align both the mind and body.
Yoga Bronx classes are held in the area, and offer a great system that combines stretching and strengthening exercises with the mind disciplining addition of meditation. Yoga classes set the stage for a relaxed and welcoming atmosphere. Various sessions of yoga can focus on the beginner and also the more experienced yoga experts. Yoga helps anyone to enjoy moving and concentrating and becoming more aware. Whether you choose a Pilates or a Yoga trainer in New York City, you?re sure to find the class and the instruction that is just right for you. Whatever your degree of physical and mental fitness might be right now, you can become even more proficient and find greater happiness in being healthier in mind and body.
Remember to see your primary care physician for a physical before starting any fitness or weight training program. Despite a recent published study casting doubt on its necessity, a complete annual check up should be a part of everyone?s wellness plan. A simple yearly visit to your doctor can help identify the start of what could become a chronic or serious health problems later on. If you are at risk for any health problems, whether through your current lifestyle or family medical history, you will want to know this before you get started. As an extra motivator, this will give you an accurate before and after comparison when it comes time to do your fitness assessments.
Learn more about pilates Bronx. Stop by Jordan Glenn?s site where you can find out all about Bronx Yoga and what it can do for you.
Did you know that you can lose bellyfat by eating certain foods? As unbelievable as that sounds. The experts have always advised you to starve in order to lose any type of fat. Now, the foods that I will tell you about don?t contain any special metabolism-boosting chemicals that can help you with fast weight loss.
Its a known fact that your body needs to burn a lot of calories. Just to digest these ?special? foods. You may not be aware, the more calories you burn, the quicker you will lose belly!
When we start to become older, our metabolic rate slows down considerably! Ever wondered why alot of people gain weight once they reach middle age? During middle age, a person?s metabolic rate becomes low; therefore he is not able to burn as much fat as he used to during his younger days. eating these ?special? foods is, a good way of boosting your metabolic rate! In this article I will talk about some of these foods:
1. Green Tea: If you drink morning tea, replace it with green tea! Ordinary tea is so so, but green tea is the best It contains fat burning chemicals which helps you with weight loss an belly fat. This is the reason that many of the weight loss supplements in the market have green tea as a common ingredient!
2. Peanut butter: Peanut butter should be used to replace ordinary butter. Unlike the ordinary butter, peanut butter is rich in protein and fiber, both of which will help you with fat loss. While protein will help you burn fat by building lean muscle mass, fiber will help in suppressing your appetite for hours.
Most local stores carry Peanut butter. We recommend that you buy the natural ones. Peanut butter makes for a great breakfast when combined with wholegrain wheat bread!
3. Almond: There are two types of fat available: the good and the bad fats. The bad fats should be avoided! The good fats supply your body with essential nutrients such as fatty acids. Almond is one such food. It is rich in fatty acids and protein. Almond helps you burn belly fat by boosting your metabolic rate!
4. Beans: The very best way to suppress your hunger. Beans make for a great appetite supplement. Since they are rich in fiber, they help to keep your stomach full but will not add fat. click here
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Any time you would like a position to be a medical helper, or perhaps almost any task for that matter, you are likely to need to create ones application plus your skills stick out from various other people. Any employment cover letter also need to end up being incorporated with your own job application and also is going to enable organisations to find out which that you are along with what your current skills are usually. Is it doesn?t initial thing organisations discover after you mail these people the resume, along with shows why you need to become selected above an additional candidate. It is best to mention several of the belongings that make a person qualified to apply for the position you?re applying for.
Whenever you make application for a situation with a doctor workplace, make certain you study as much as you are able to regarding the facility plus the physician. Learn about what on earth is performed at this time there in addition to complete a number of study on-line. This way, in case you are referred to as set for a meet with, you will definitely have the ability to win over these with your know-how along with taking the time to find out around the facility. You should make sure that your particular ability along with continue really should complement the requirements on the ability or maybe your physician. Consequently if your center involves people work weekends or some other creepy or perhaps non-traditional several hours that you simply express as part of your resume or perhaps resume cover letter that you?re prepared operate these types of several hours.
When building the employment cover letter preserve that professional searching. You should make sure that you make use of a font that may be readable in addition to with a measurement that is certainly readable as well. Occasions News Roman is an excellent font make use of along with dimensions 12 seems to be the standard at the same time. Try and keep your employment cover letter as well as your resume to 1 web site every single. Don?t get a lot of in greater detail however always be comprehensive ample. You do not need there to become numerous web pages as they could easily get dropped.
Ensure the health-related asst cover letter is just a single site. On the resume you should just remember to get referrals extra also. Most of these must be expert referrals for example your own teacher at school or perhaps a past boss that can pass on good things about you. A new medical asst employment explanation is different and for that reason you should make certain you mention numerous abilities you possess. You should handle a number of requirements which can be from the career placing. For instance, in the event the work publishing says you will end up carrying out light-weight business office operate, talk about that you?ve got office encounter.
Ensure ones job application letter is problem free along with you will discover zero grammatical glitches. This can possess a heavy influence on the possibility with staying regarded as for that work. You can be fighting with other folks for your very same career for the reason that industry and require pertaining to health-related assistants is usually soaring. You ought to just remember to job application letter carries a concluding as well as expresses your current interest in the position. Declare that additional information and also particulars can be found, in addition to close up using your identify.
I think you have experienced an event of this specific mind condition. These kinds of head states are common within youngsters, yet many grown ups forget about how to accessibility all of them.
If you?ve certainly not encountered this intellect talk about written, next I believe you have knowledgeable the same talk about after you were being undertaking another action. Maybe it was boating, going for walks, or bouncing, or perhaps listening to audio.
Seek to create some sort of head condition through which you happen to be completely comfortable and yet fully aimed. Here is the maximum state in which to publish.
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Treasury Secretary Timothy Geithner testifies on Capitol Hill in Washington, Thursday, July 26, 2012, before the Senate Banking Committee hearing: "The Financial Stability Oversight Council Annual Report to Congress." (AP Photo/Haraz N. Ghanbari)
Treasury Secretary Timothy Geithner testifies on Capitol Hill in Washington, Thursday, July 26, 2012, before the Senate Banking Committee hearing: "The Financial Stability Oversight Council Annual Report to Congress." (AP Photo/Haraz N. Ghanbari)
BERLIN (AP) ? U.S. Treasury Secretary Timothy Geithner is to meet his German counterpart and the head of the European Central Bank on Monday following a flurry of pledges to save the euro that raised expectations of decisive action soon. Germany, however, appeared to downplay those hopes.
Geithner will meet Finance Minister Wolfgang Schaeuble on the North Sea island of Sylt, where Schaeuble is vacationing. After the meeting, which Germany says was initiated by the U.S., Geithner will travel to Frankfurt to meet ECB President Mario Draghi.
Finance Ministry spokeswoman Marianne Kothe said only that Geithner and Schaeuble would hold informal talks and the question of the euro would be discussed.
Markets surged after Draghi said last Thursday that the ECB would do "whatever it takes" to preserve the euro. Over the following days, the leaders of Germany, France and Italy also said they would do all they can to protect the 17-country currency union.
Though they didn't pledge any specific action, the comments raised expectations that the ECB might step in to buy Spanish and perhaps Italian government bonds to lower the countries' borrowing costs, which have been worryingly high in recent weeks. Another possibility might be for the eurozone's temporary rescue fund, the European Financial Stability Facility, to buy bonds.
In an interview with Monday's edition of the German daily Sueddeutsche Zeitung, Jean-Claude Juncker ? the Luxembourg prime minister who chairs meetings of the eurozone finance ministers, or eurogroup ? said that officials have no time to lose and will decide in the coming days what measures to take.
Juncker said the rescue fund and eurozone countries would coordinate with the ECB ? "and we will, as Draghi says, see results." But he also said: "It still has to be decided what exactly we will do when. That depends on the developments of the coming days and how fast we have to react."
Asked what exactly was meant by German Chancellor Angela Merkel's joint statements with her French and Italian counterparts, German government spokesman Georg Streiter said Monday: "It is the intention of all simply to send a very strong signal for the euro." He also highlighted Juncker's comment that what will be done ? and when ? still has to be decided.
Streiter didn't talk about any specific action, other than to make clear that Germany still opposes any move to pool government debt, for example through jointly issued eurobonds.
Previous bond purchases by the ECB haven't been popular in Germany, where some worry that they go beyond the central bank's mandate. Without commenting directly on the possibility, Streiter said that "the German government has full confidence in the ECB."
LONDON ? The queen of England was persuaded to take part in her hilarious Opening Ceremony act with James Bond following a personal plea from her favorite movie director.
The English monarch made an exception to her public policy of speaking only in formal settings in order to perform a scene with Bond actor Daniel Craig that ended with stunt doubles resembling the pair leaping from a helicopter above the Olympic Stadium.
[ Related: Queen causes stir in athletes' village ]
The segment stole the show Friday night and was made possible after Danny Boyle, the brains behind the ceremony and an award-winning director, used the queen's love of his greatest film ? "Slumdog Millionaire" ? to his advantage.
"The queen made herself more accessible than ever before," Boyle said.
Yet her majesty may not have agreed to the highly unconventional request if it had not come from Boyle himself. It is not known whether Boyle realized this or not, but the entire royal family is huge fans of his work and have watched "Slumdog Millionaire" on countless occasions.
Princes William and Harry, the queen's grandsons, joined the "Slumdog" craze in 2008, when the film broke box-office records and walked away with eight Academy Awards.
[ Photos: London Games Opening Ceremony ]
William's wife, Kate, is also an admirer, as is his father, Prince Charles, and Charles's wife, Camilla, as well as cousin Zara Phillips, who is competing in the Olympic equestrian events. The queen watched the movie on the advice of her grandchildren and made no secret of her enjoyment of the production, which followed the journey of an orphaned Indian boy from the slums of Mumbai.
"It is very much a favorite," a royal source said. "The queen watched it after being encouraged by William, Harry, and others and liked it so much she saw it again. That certainly didn't hurt when Mr. Boyle made his request for her royal highness to be involved in the Games in an extra role beyond her official capacity."
The Bond story reflected what has been a noticeable softening in the public persona of the queen in recent years. The image of the royal family was at a significant low point following the death of Diana, princess of Wales, and the queen has since tried to convey a more down-to-earth personality.
[ Related: NBC blasted for not showing Opening Ceremony live ]
The royal video saw Bond driven into the grounds of Buckingham Palace in the back of a black London taxicab before being led to meet the queen, who was writing at a desk. She turned to face him and uttered the single line: "Good evening, Mr. Bond."
Agent 007 and the monarch then climbed aboard a Westland helicopter, which took off into the London skies, then "reappeared" at the stadium for one of the greatest moments of an outstanding event.
Related Olympic video from the Yahoo! Sports network:
More Olympic coverage from the Yahoo! Sports network: ? What to watch for: Olympics first weekend ? Jet Nick Mangold moving mountains to watch sister in Olympics ? Lolo Jones shows Tyson Chandler way too big for Olympic village beds
When you know how to change things up a bit, you can derive the maximum value of and appreciation for your living area. Be certain you are aware of what you have to do, and that you do it right. This way, you can ensure your satisfaction and money?s worth from your home improvement efforts, with the great advice in this article!
Rather than replacing your kitchen cabinets, what about refinishing them? Paint the bases, replace fixtures and get new doors for a brand new kitchen. You will modernize your entire kitchen without spending a lot of money.
There are many different kinds of screws. Know what type of screw is required for the different projects around the home. Wooden screws often work better with wood projects, as they will easily be twisted through the wood. When working with sheet metal, there are special screws available also.
Try and predict any unexpected costs you might incur in advance. Unexpected expenditures can really add up, and one mistake can break your entire budget. You can stop this from happening by doing a lot of planning. This will help you stay flexible if something goes wrong, such as a key material not being in stock.
An easy home improvement idea is to replace old appliances with newer, cost effective ones. Upgrading old appliances could eventually pay for themselves due to them being efficient in their energy consumption. Installing appliances is fairly simple and makes a nice home improvement option.
A home improvement project done properly can add value to your home. Done improperly, it can be the source of an unending headache. Hopefully, you have found a lot of helpful advice in this article that will get you on your way to successful and satisfying home improvement projects today
Helpful roofing contractors richmond Tips For Successful Home Improvement Projects
Home improvement can be an important part of your life because you are personalizing your home. You need to do all of your research so that you don?t wind up losing a ton of money or even harming yourself or your loved ones. There are some tips listed below to help you begin.
Put your used paint brushes and rollers in plastic and in the fridge! If you are going to continue using the same paint in the near future there is no reason to wash out your brushes and rollers. Just seal them in a plastic bag and put them in the refrigerator. They will be usable for weeks!
When improving your house, there are some projects that you can do yourself and others that you cannot. If you feel like you can complete a simple task like repainting the kitchen, then by all means do it, in order to save yourself some extra money. Just be sure that you know what you?re getting yourself into before you start a project. You don?t want to try and remodel your bathroom and find out half way through that you?re not sure if you can complete the task without hitting a pipeline.
Make sure before you get started in remodeling your basement that you have kept in mind heating, cooling, proper ventilation and dehumidification of the area. If you have enough headroom, your heating, cooling and much of your electrical equipment can be hidden behind a false ceiling. Prepare to hire a heating contractor to help you with your basement project.
Reuse as much as possible during your home improvement kingston roofing contractor to save money and help the environment. If you can paint your cabinets to give them a new look, why not? Replace the knobs or handles on them as well to modernize their look. Consider painting tile instead of replacing it to freshen a room.
When renovating your kitchen, avoid tiled counters. Tiled countertops are less sanitary than granite or mock-stone countertops, because food and other contaminants can build up in the spaces between the tiles. Tile countertops can also crack or even shatter if a heavy dish is dropped onto them, unlike countertops made of more modern materials.
If you have small holes in your wall from hanging paintings or pictures, use spackle and paint to make your walls look new again. First, buy spackle at a home improvement store. If the holes aren?t too large, you will just need a small amount of spackle. The smallest holes can be filled by applying spackle from the end of a bobby pin. Once the spackle dries, smooth over the hole with something rigid (like a credit card) so the wall is smooth. Apply paint. This will make the holes in your wall disappear overnight!
If you are going to do home improvements to an entire property and not just one room, make sure you have a concise idea from the outset of what you are wanting to achieve. Making major alterations to plans mid project will not only cost money, but could also lead to issues with any contractors working for you.
Consulting with a professional is a necessary step in any home improvement project. While it can be fun to design your own project kingston roofer and this is something you are definitely allowed to do, a professional can give you information that you may not have otherwise found out about. Such information can include zoning restrictions and environmental laws. The last thing you want is for a building inspector to come and tell you to tear down your project, after you have finished.
Landscaping can easily add value to your home by creating curb appeal. Shrubs and hedges are generally affordable and easy to maintain. Trees, on the other hand, are not recommended for many reasons. Foremost, immature trees do little to enhance the attractiveness of a yard, while mature trees are often very expensive.
Extension cords and cables can easily get tangled. There is nothing more annoying than reaching for an extension cord and realizing that it is tangled. A great way to keep your extension cords from tangling, is by coiling them neatly into a bucket when not in use. This way, when you need them, you can just reach in and use.
To make the roof on your real estate last as long as possible you should make sure there are power vents installed to draw hot air out of the attic space. This will keep the underside of the roof cooled down so that it does not cook your shingles the way a frying pan cooks and egg.
Home improvement can be very rewarding, but it can also be a lot of work. Regardless, if you know what to do and how to properly and safely improve your home, you can create the house of your dreams. So, do yourself a favor by doing your research and applying the above tips to your home improvement.
When Hyleas Fountain was in eighth grade, she watched the state track-and-field meet, turned to a Central Dauphin East High School coach and vowed to compete there the next year.
She did. And that was just the beginning.
Fountain is scheduled to compete Aug. 3 and 4 in the Olympics heptathlon in London as she aspires to win her second Olympic medal. She won the silver medal in the heptathlon at the 2008 Olympics in Beijing.
The opening ceremonies take place today.
The former Swatara Twp. resident always knew how to make her dreams come true, said Al Moten, the former CD East track coach.
?I knew Hyleas was special from the first time I coached her,? said Moten, who was Fountain?s coach from ninth through 12th grades. ?An athlete like that comes to a coach every 15 or 20 years. I was blessed to coach her.?
Moten is optimistic that the 31-year-old Fountain can win another medal in the grueling event. The heptahlon includes the 100-meter hurdles, high jump, shot put, a 200-meter dash, long jump, javelin and 800-meter run.
Fountain, a 2000 graduate of CD East, is especially strong in the long jump. She once jumped 19? feet at Landis Field, and later jumped 23 feet, Moten said.
He said she is equally strong at the high jump, noting that she jumped 6 feet when she was a junior.
?Hyleas also is a very determined, strong runner,? said Moten, who is now an administrator at Gaudenzia and assistant pastor of Shiloh Church of God in Christ in Swatara Twp.
?In high school, she distanced herself from other females because she was at a much higher level. She always tried to do better, but she was humble and teachable, too.?
Moten called Fountain one of the star athletes in his coaching career, which also included Elizabethtown College and Lebanon Valley College.
By the time Fountain was a senior, competing against girls offered little challenge. Moten said she began competing against boys in track-and-field events, frequently winning. He said people came to the meets to watch the high school girl compete against the boys and beat them in the high jump.
?Hyleas would follow any suggestion I gave her, always trying to do better,? Moten said. ?She?s a sweet, humble kid who doesn?t feel she?s above everyone. She?s there for the team and encourages the other athletes.?
Yet even Fountain had her off days. After winning four gold medals at the district track-and-ield meet during her senior year, she had high hopes heading to the state meet in Shippensburg.
Instead, she was injured during her first event, which hindered her the rest of the day. She fell in her last race. She didn?t win any medals.
?When she cried, I told her that there would be better days ahead,? Moten said. ?Then we went to dinner at Red Lobster. She put everything behind her. Most kids would have ended their athletic careers there. Hyleas didn?t. That day became the catalyst that she wanted to make up for and do better. And she did. She has a great attitude.?
Fountain trains hours each day for the heptathlon. To keep her lean and muscular build, she eats a lot of fruits, vegetables and beans, some fish and a little meat.
Moten, who coached at Central Dauphin East for 15 years, follows Fountain?s competitions closely.
?I?m very proud of her,? he said. ?Next week will be ?Hyleas Fountain Week.? All eyes will be on her.?
Always an athlete
Fountain?s love of all things athletic date to her childhood, when she went to the Bressler and Oberlin parks to play and rode her bicycle through the ?triple cities? of Bressler, Oberlin and Enhaut.
As a 7-year-old, she ran competitively with the Harrisburg High Steppers.
She competed in the Swatara Twp. Recreation Department?s summer events, and won ribbons in field events at Tri-Community Elementary School and in track events at Central Dauphin East Junior High School.
By the time Fountain was in high school, she had hit her stride, Moten said.
The Olympics will feature another product of the Central Dauphin School District.
Ryan Whiting, a Central Dauphin High School graduate, will compete in the shot put.
?Hyleas and Ryan were good students, good teammates and represented our school district in their high school careers and beyond with class and integrity,? said Ford Thompson, Central Dauphin School Board president. ?Their achievements speak very loud and clear to their superior athleticism. Even more important, both are such quality people.?
More Olympics on PennLive.com
Olympics will provide plenty of action for any kind of fan ? Your weekend Olympics guide: Opening ceremony, local Olympians and more ? Six unusual Olympic sports of today and four from yesteryear ? Full Olympics coverage ?
Many businesses question the value of quarterly review meetings, considering the cost and time required for preparation and execution that could have been spent elsewhere. But experts agree that businesses that invest in quarterly reviews have a greater chance of meeting their goals and succeeding in the marketplace.
According to a Harvard Business Review blog post on best practices, titled Four Fatal Flaws of Strategic Planning (Ed Barrows, March 13, 2009,) number four on the list is: ?Dodging Strategy Review Meetings.? Enough said.
At Communiqu?, we believe quarterly reviews are an essential piece of the strategic plan and value partnerships with clients who share this belief. One example is Tecplot Inc. They invest regularly in quarterly review meetings and have experienced first-hand the inherent benefits. Having just participated in another productive quarterly review with their marketing team, we are reminded of the value. Here are some things to consider:
Why invest in quarterly review meetings:
Think of a quarterly review as a quarter break or time-out in an NBA game. Why don?t the players just keep playing and trying to win? They watched the films and had a plan before the game started. The answer is simple: time-outs allow the coach and team a chance to pause, discuss how the game is going and adjust strategy to ensure the best possible outcome. They do this throughout the game so they can course-correct while there is still time.
The same strategy applies to business. If you only review your success once you execute against your annual strategic plan, you are only able to reflect on what worked and what didn?t. There is no time left to change what wasn?t working. Strategic plans should be living documents and companies should be flexible enough to change course when needed. Changing a plan is not necessarily a sign that the original plan was weak.
Why might you need to course-correct if you?ve developed a good strategic plan at the outset? Strategic decisions are based on the knowledge you have about your business at that time and the assumptions you make about the business environment. And the assumptions are many: the appeal of your product or service, opportunities that lie ahead, competitive threats and/or roadblocks. You can only plan based on what you assume will happen. What actually happens remains to be seen. A quarterly review allows you to take stock of which of your assumptions have played out as expected and to what extent.
Other factors may also affect your strategy that cannot be planned for in advance, such as big events or market changes that might impact your product (think 911 if you?re in the travel industry or the fast rise of the iPod if you?re in the business of CD players.) Also, new opportunities might pop up that you hadn?t anticipated. Are they more or less valuable than the opportunities you targeted in your plan? The quarterly review allows you to factor in these changes and adjust the plan accordingly.
Tips for a successful quarterly review:
Planning for quarterly reviews should not be an arduous task. Ideally, the data should already exist in weekly or monthly status reports. This data can be pulled, summarized and analyzed for the quarterly review. There should not be much new data shared at the quarterly review, but it?s a chance for deeper analysis of what is already known with corresponding strategic ?regrouping?.
The quarterly review should be a broad look at the business addressing large functional areas together, rather than each piece individually (for example, the entire marketing team rather than a PR-specific review.) As such, the review allows you to hear what other cross-functional teams are doing and ensures a greater chance for integration and consistency.
Successful quarterly reviews should also be held in person where all participants are in the same room, if possible. In today?s perennially ?connected? world, employees are often disconnected physically with many working remotely or simply working heads-down in their office and communicating mostly via email even with colleagues down the hall. Quarterly reviews allow the team to pull back from the day-to-day work, and have a chance to think more strategically and collaboratively. And the chance to come together in-person also results in more cohesive teams and a higher functioning organization.
Tags: cohesive teams, higher-functioning organization, strategic decisions, successful quarterly reviews, the value of quarterly review meetings, why we invest in quarterly review meetings
If you are building or renovating your residence, you must have feel the want for certified contractor. You can do various work manually for your house, but still there are many things that can be finished only by individuals who are expert in the field. It is significant to take the assist of licensed contractors, when you believe about the cabling of your residence. UAC is the foremost online resource for finding expert, qualified contractor in your area. With a snap of the mouse, you will have admission to countless local home improvement, and remodel experts with specialty that will fit your requirements. At UAC, our object is to join you with pre-screened, qualified contractors in your area. You will have the capability to find the top rates, and best quality and craftsmanship vacant. We present outstanding service and information that is very precious when preliminary and house improvement / remodel task. We struggle to provide easy access through this website and craft finding a contractor, a easy, more capable course.
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State stem cell research funding agency awards $20 million to UCI, StemCells Inc.Public release date: 27-Jul-2012 [ | E-mail | Share ]
Contact: Cathy Lawhon clawhon@uci.edu 949-824-1151 University of California - Irvine
Funds will advance joint project to treat spinal cord injury
Irvine, Calif., July 26, 2012 Efforts to begin human clinical trials using stem cells to treat cervical spinal cord injury in the U.S. received a $20 million boost Thursday, July 26, from the state's stem cell research funding agency, the California Institute for Regenerative Medicine.
The award will be shared by Aileen Anderson and Brian Cummings, associate professors of physical medicine & rehabilitation at UC Irvine's Sue & Bill Gross Stem Cell Research Center, and Nobuko Uchida of StemCells Inc. in Newark, Calif. Anderson and Cummings proved that transplanting human neural stem cells discovered and developed by Stem Cells, Inc. into rodents with thoracic spinal cord injury could restore mobility. The CIRM award announced Thursday will fund the collection of data necessary to establish human clinical trials in the U.S.
"Our therapeutic approach is based on the hypothesis that transplanted human neural stem cells integrate into the injured spinal cord to repair the protective myelin sheath and spinal circuitry," Anderson said. "Any therapy that can partially reverse some of the effects of spinal cord injury could substantially change the quality of life for patients by altering their dependence on assisted living and medical care."
CIRM's governing board on Thursday gave authorized $150 million for eight teams at five institutions statewide. The projects backed are considered critical to the institute's mission of translating basic stem cell discoveries into clinical cures.
"CIRM's support for UC Irvine's efforts to advance novel stem cell-based therapies for a variety of diseases is extremely gratifying," said Peter Donovan, director of the university's Sue & Bill Gross Stem Cell Research Center. "This latest award for spinal cord treatment holds great promise. We are delighted."
About 1.3 million Americans suffer chronically from spinal cord injuries. In California, nearly 147,000 individuals are living with such damage, which can severely impair the movement, sensation and autonomic function of otherwise healthy people. Recovery from spinal cord injury is often limited, even after aggressive emergency intervention with steroids and surgery, followed by rehabilitation.
"That's crushing for anyone," Anderson noted. "It's very tough for patients and their families. We believe stem cell therapies could provide significant functional recovery, improve quality of life and reduce the cost of care for those with spinal cord injury. That's our goal."
Anderson's and Cummings' laboratory has a long history of collaboration with StemCells Inc. in addressing spinal cord injury, including studies that led to the world's first clinical trial of a neural stem cell therapy for chronic spinal cord injury. This Phase I/II clinical trial, currently under way in Zurich, recently reported positive safety data from the first cohort of treated patients and continues to enroll subjects.
"We are very encouraged by the preliminary results in these volunteers" Cummings said, "and we are excited to receive CIRM funding to enable us to extend this approach to those with cervical injuries and to patients in the U.S."
###
About CIRM: Established in November 2004 with the passage of Proposition 71, the California Institute for Regenerative Medicine is authorized to provide $3 billion in funding over 10 years for stem cell research and facilities throughout California.
About the University of California, Irvine: Founded in 1965, UCI is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UCI is among the most dynamic campuses in the University of California system, with nearly 28,000 undergraduate and graduate students, 1,100 faculty and 9,000 staff. Orange County's second-largest employer, UCI contributes an annual economic impact of $4 billion. For more UCI news, visit www.today.uci.edu.
News Radio: UCI maintains on campus an ISDN line for conducting interviews with its faculty and experts. Use of this line is available for a fee to radio news programs/stations that wish to interview UCI faculty and experts. Use of the ISDN line is subject to availability and approval by the university.
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State stem cell research funding agency awards $20 million to UCI, StemCells Inc.Public release date: 27-Jul-2012 [ | E-mail | Share ]
Contact: Cathy Lawhon clawhon@uci.edu 949-824-1151 University of California - Irvine
Funds will advance joint project to treat spinal cord injury
Irvine, Calif., July 26, 2012 Efforts to begin human clinical trials using stem cells to treat cervical spinal cord injury in the U.S. received a $20 million boost Thursday, July 26, from the state's stem cell research funding agency, the California Institute for Regenerative Medicine.
The award will be shared by Aileen Anderson and Brian Cummings, associate professors of physical medicine & rehabilitation at UC Irvine's Sue & Bill Gross Stem Cell Research Center, and Nobuko Uchida of StemCells Inc. in Newark, Calif. Anderson and Cummings proved that transplanting human neural stem cells discovered and developed by Stem Cells, Inc. into rodents with thoracic spinal cord injury could restore mobility. The CIRM award announced Thursday will fund the collection of data necessary to establish human clinical trials in the U.S.
"Our therapeutic approach is based on the hypothesis that transplanted human neural stem cells integrate into the injured spinal cord to repair the protective myelin sheath and spinal circuitry," Anderson said. "Any therapy that can partially reverse some of the effects of spinal cord injury could substantially change the quality of life for patients by altering their dependence on assisted living and medical care."
CIRM's governing board on Thursday gave authorized $150 million for eight teams at five institutions statewide. The projects backed are considered critical to the institute's mission of translating basic stem cell discoveries into clinical cures.
"CIRM's support for UC Irvine's efforts to advance novel stem cell-based therapies for a variety of diseases is extremely gratifying," said Peter Donovan, director of the university's Sue & Bill Gross Stem Cell Research Center. "This latest award for spinal cord treatment holds great promise. We are delighted."
About 1.3 million Americans suffer chronically from spinal cord injuries. In California, nearly 147,000 individuals are living with such damage, which can severely impair the movement, sensation and autonomic function of otherwise healthy people. Recovery from spinal cord injury is often limited, even after aggressive emergency intervention with steroids and surgery, followed by rehabilitation.
"That's crushing for anyone," Anderson noted. "It's very tough for patients and their families. We believe stem cell therapies could provide significant functional recovery, improve quality of life and reduce the cost of care for those with spinal cord injury. That's our goal."
Anderson's and Cummings' laboratory has a long history of collaboration with StemCells Inc. in addressing spinal cord injury, including studies that led to the world's first clinical trial of a neural stem cell therapy for chronic spinal cord injury. This Phase I/II clinical trial, currently under way in Zurich, recently reported positive safety data from the first cohort of treated patients and continues to enroll subjects.
"We are very encouraged by the preliminary results in these volunteers" Cummings said, "and we are excited to receive CIRM funding to enable us to extend this approach to those with cervical injuries and to patients in the U.S."
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About CIRM: Established in November 2004 with the passage of Proposition 71, the California Institute for Regenerative Medicine is authorized to provide $3 billion in funding over 10 years for stem cell research and facilities throughout California.
About the University of California, Irvine: Founded in 1965, UCI is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UCI is among the most dynamic campuses in the University of California system, with nearly 28,000 undergraduate and graduate students, 1,100 faculty and 9,000 staff. Orange County's second-largest employer, UCI contributes an annual economic impact of $4 billion. For more UCI news, visit www.today.uci.edu.
News Radio: UCI maintains on campus an ISDN line for conducting interviews with its faculty and experts. Use of this line is available for a fee to radio news programs/stations that wish to interview UCI faculty and experts. Use of the ISDN line is subject to availability and approval by the university.
[ | E-mail | Share ]
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
WORLD NEWS TOMORROW -According to the Norwegian newspaper Aftenposten, there were concrete plans to assassinate Norwegian peace envoy to Sri Lanka, Erik Solheim when he visited Colombo in May of 2000.
Solheim, who was chief peace mediator on behalf of the Norwegian Department of Foreign Affairs, in the conflict between the governing Singhalese and the Tamil population, came to have talks with Sri Lanka?s President Chandrika Kumaratunga, together with State Secretary Raymond Johansen.
The newspaper writes that a bomb attack was planned against Solheims convoy of cars. However, strict security measures are said to have prevented the attck, Aftenposten writes.
ScienceDaily (July 26, 2012) ? Researchers from the University of Kentucky have designed and discovered a series of highly efficient enzymes that effectively metabolize cocaine. These high-activity cocaine-metabolizing enzymes could potentially prevent cocaine from producing physiological effects, and could aid in the treatment of drug dependency.
The results of this study by Chang-Guo Zhan et al are published in the journal PLOS Computational Biology.
The effectiveness of the enzymes' work was evaluated through modeling cocaine pharmacokinetics, the study of the body's action on administered external substances, such as cocaine, when the enzyme exists in the body. As there is no FDA-approved anti-cocaine medication, the medical and social consequences of cocaine abuse have made the development of anti-cocaine medication a high priority.
Administration of an enzyme to enhance cocaine metabolism has been recognized as a promising treatment strategy for overdose and abuse. A remarkable feature of the enzyme-based therapeutic approach is that one enzyme molecule can degrade many thousands of drug molecules per minute.
This pharmacokinetic modelling is a crucial step of enzyme-based therapy development for cocaine abuse. Furthermore, the general insights of the research should also be valuable for future development of an enzyme therapy for any addictive drug, as the general methodology of the modelling may be used to develop valuable models for evaluating the effectiveness of metabolic enzymes in detoxifying other drugs.
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Journal Reference:
Zheng F, Zhan C-G. Modeling of Pharmacokinetics of Cocaine in Human Reveals the Feasibility for Development of Enzyme Therapies for Drugs of Abuse. PLoS Comput Biol, 2012 DOI: 10.1371/journal.pcbi.1002610
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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Anthony Hayne pleaded to all three counts against him in US District Court. His attorney, Michael O'Shea, said Hayne hopes to get leniency in return for his testimony.
By Associated Press / July 25, 2012
This undated file photo provided by the FBI shows Anthony Hayne, one of five men charged with plotting to bomb a highway bridge in Ohio pleaded guilty in federal court in Akron, Ohio, on July 25, and will testify against his co-defendants.
FBI/AP/File
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One of five men charged with plotting to bomb an?Ohio?highway bridge made a surprise guilty plea Wednesday and agreed to testify against his co-defendants.
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Anthony Hayne, 35, pleaded to all three counts against him in US District Court. His attorney, Michael O'Shea, said Hayne hopes to get leniency in return for his testimony.
Authorities have called the men anarchists. Investigators say the group planted what turned out to be a fake bomb provided by an FBI undercover informant on a bridge south of Cleveland and repeatedly tried to detonate it using text messages from cellphones.'
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The defendants could face life in prison if convicted.
Under the terms of the plea deal, Hayne will have the chance to avoid a life prison term. He could face 15 years to nearly 20 years in prison.
"I don't think any of these guys intended harm to human beings," O'Shea said. "I think they just thought this was a way of making some sort of political statement. But I'm relatively confident none of these people had any desires to actually hurt anybody."
O'Shea said Hayne was a latecomer to the alleged plot and had the least standing to argue that he had been manipulated by an FBI informant.
The five had been associated with the Occupy Cleveland movement, part of a national demonstration last year against economic inequality, but organizers of the movement have tried to distance the group from the men. They say the five didn't represent it or its nonviolent philosophy.
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NEW YORK (AP) ? Zynga's stock is tanking after the online game maker reported a loss in the second quarter, with adjusted earnings and revenue below Wall Street's already-low expectations.
The company behind games such as "CityVille" and "FarmVille" also lowered its outlook for the year because of delayed games, reduced expectations for its "Draw Something" game and what it called a "more challenging environment on the Facebook Web platform."
Zynga derives nearly all of its revenue from games played on Facebook, and a growing number of Facebook users are accessing the social network using mobile devices rather than computers. That hurts Web-based games such as Zynga's.
Zynga Inc. said Wednesday that it lost $22.8 million, or 3 cents per share, in the April-June quarter. That's down from earnings of $1.4 million a year ago when it was still privately held. Its per-share results last year were at breakeven.
Adjusted earnings in the latest quarter were a penny per share, below expectations of 5 cents per share.
Zynga's revenue grew 19 percent to $332 million. Analysts surveyed by FactSet had expected $342.8 million.
Zynga had a lot riding on this quarter. Investors had been punishing its stock because of worries about declining user numbers.
But the results provided no relief. Zynga's stock sank $2.09, or 41 percent, to $2.99 in after-hours trading after the results came out. The stock had closed up 16 cents at $5.08 during the regular session.
Facebook's stock also declined after Zynga's announcement. The bad news from Zynga could hurt Facebook, which reports its earnings on Thursday. Facebook's stock fell $2.54, or 8.7 percent, to $26.80 in after-hours trading.
Zynga also said Wednesday that its chairman and CEO, Mark Pincus, became the beneficial owner of more than 50 percent of the company's voting power through stock he owns.
Bear at mall: Over the weekend, shoppers at the Pittsburgh Mills Mall were greeted by a black bear who entered a Sears store. Two hours later, a second bear was spotted near the mall's Olive Garden. Wildlife officials set a trap Monday to relocate the second bear.
By Associated Press / July 24, 2012
Bear at mall: Two bears were spotted at a mall near Pittsburgh over the weekend, prompting wildlife officials to set a trap for one Monday afternoon. Here, Pennsylvania Game Commission wildlife conservation officer Jacob Olexsak, left, helps lift a black bear that was tranquilized while it was up a tree located in the backyard of the home in Erie, Pa., on July 22, 2012.
Janet B. Kummerer/Erie Times-News/AP
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The Pennsylvania Game Commission worked to set a trap Monday afternoon after mall-goers in Frazer encountered not one, but two bears at a mall.
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Local media reported that at about 9 p.m. a 125-pound bear walked around a Sears store at the Pittsburgh Mills Mall for about 10 minutes and growled at customers, then became stuck between double doors.
After the customers evacuated the store, the Pennsylvania Game Commission tranquilized the bear and removed it from the mall, which is about 15 miles northeast of Pittsburgh. No injuries were reported.
Authorities say they have no idea why the young bear walked across a parking lot, through doors and into the Sears store. The bear appeared to be around 1 1/2 years old and had a tracking collar on it.
A second bear emerged later near an Olive Garden restaurant at the mall around 11:45 p.m. Saturday. That was less than two hours after officials tranquilized the first bear that had gotten inside a Sears store.
Officials say the second bear was not captured and then reappeared around 7:45 p.m. Sunday, backing up traffic on a nearby highway.
According to the Pittsburgh Post Gazette, wildlife authorities set a trap Monday afternoon in order to capture the bear. The trap is a large canister with camouflage paint and the words "Danger Bear Trap." They will use Hostess Mini Muffins and Ding Dongs to attract the bear.
Google's bringing tradition and technology closer together?by putting a digital spin on the holy month of Ramadan.
As explained in a blog post by?Maha Abouelenein?? Google's head of communications for the?Middle East and North Africa???the search engine giant will have a YouTube channel dedicated to sharing Islamic prayers live from Mecca, a new YouTube channel which will offer 50 "premium Ramadan shows" on the same day that they air, and?Google+ Hangouts which will begin?after sundown.
The Google+ Hangouts will coincide with the traditional?evening break-the-fast meals (called the "Iftar") and involve celebrity chefs who will share recipes, doctors who will give pointers on healthy eating habits, actors who'll talk about their favorite Ramadan shows, poets, religious figures and more.
The Google Arabia page on Google+ offers more info on these events and activities.
Want more tech news?or interesting?links? You'll get plenty of both if you keep up with Rosa Golijan, the writer of this post, by following her on?Twitter, subscribing to her?Facebook?posts,?or circling her?on?Google+.
This morning we heard that the Marlins are making Hanley Ramirez available. Bob Nightengale reports that he?s in demand:
He?d represent an upgrade for the A?s, no doubt. At least if you don?t think Brandon Inge is gonna carry that team offensively. In Boston and Toronto he?d make more sense as a shortstop. ?In all cases, he?s a gamble: will the change of scenery make him what he once was? Or will he be a $31.5 million+ bust?
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Mortgage refinance is a way in which a person works with a lender to get a new loan for building an apartment or house. When that person obtains the new loan then he/she use that money to pay an older mortgage loan. In this way one can pay their existing loan so that the loan term and mortgage lender has been reset. But sometime one works with a lender to take a new loan. There are many reasons of re-financing-
a) Lower interest Rate b) Pay bills c) Replace any mortgage.
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But choosing a best vendor is very difficult. There are many vendors who offer different kinds of loan in Maryland. So a person should research about different vendors by gathering information from lenders and carefully choosing the profitable one. For completing an application for refinancing loan with Maryland lender of choice one need to know the payment method for the ongoing loan, details of the lender, current loan account number. The estimated value is a must. An income proof of the lender is required. Virginia refinance may be a great way that helps borrowers fulfills various money commitments. A refinance loan will help an individual to do several things besides lower monthly repayments. A Virginia refinance loan may be a smart choice for those people in Virginia who cannot meet their monthly mortgage loan payments. There are many refinance mortgage choices on the in Virginia which might facilitate within the utilizing the monthly income.
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For more information about Best Mortgage Rates and Pennsylvania Refinance , please visit:- http://www.firstchoicemoney.com/
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