The good news: If you liked Windows 8, its first major update is going fix a ton of the little things that bothered you. The bad news: You might not like Windows 8. And there's nothing here that will change that. At least there's a Start button!
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In this week's Ask A VC episode, Freestyle Capital's Dave Samuel joined us in the studio to discuss his investment philosophies and more. Samuel also talked about how and why his co-founder relationship with Josh Felser has been so successful. The duo co-founded Spinner (acquired by AOL for $320 million), and Grouper (acquired by Sony for $65 million). In 2011, Fesler and Samuel formally launched Freestyle Capital, which makes investments in early-stage startups.Source: http://feedproxy.google.com/~r/Techcrunch/~3/0WMdKagonbc/
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May 16, 2013 ? Johnny Cash may have preferred this galaxy's burning ring of fire to the one he sang about falling into in his popular song. The "starburst ring" seen at center in red and yellow hues is not the product of love, as in the song, but is instead a frenetic region of star formation.
The galaxy, a spiral beauty called Messier 94, is located about 17 million light-years away. In this image from NASA's Spitzer Space Telescope, infrared light is represented in different colors, with blue having the shortest wavelengths and red, the longest.
Starburst rings like this can often be triggered by gravitational encounters with other galaxies but, in this case, may have instead been caused by the galaxy's oval shape. Gas in the ring is being converted into hot, young stars, which then warm the dust, causing it to glow with infrared light.
The outer, faint blue ring around the galaxy might be an optical illusion. Astronomers think that two separate spiral arms appear as a single unbroken ring when viewed from our position in space.
NASA's Jet Propulsion Laboratory, Pasadena, Calif., manages the Spitzer Space Telescope mission for NASA's Science Mission Directorate, Washington. Science operations are conducted at the Spitzer Science Center at the California Institute of Technology in Pasadena. Data are archived at the Infrared Science Archive housed at the Infrared Processing and Analysis Center at Caltech. Caltech manages JPL for NASA. For more information about Spitzer, visit http://spitzer.caltech.edu and http://www.nasa.gov/spitzer .
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Public release date: 5-May-2013
Share ] Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-8413
Harvard School of Public Health
Boston, MA A new study led by researchers from Harvard School of Public Health (HSPH) and the Wellcome Trust Sanger Institute in the UK has, for the first time, used genome sequencing technology to track the changes in a bacterial population following the introduction of a vaccine. The study follows how the population of pneumococcal bacteria changed following the introduction of the 'Prevnar' conjugate polysaccharide vaccine, which substantially reduced rates of pneumococcal disease across the U.S. The work demonstrates that the technology could be used in the future to monitor the effectiveness of vaccination or antibiotic use against different species of bacterial pathogens, and for characterizing new and emerging threats.
The study appears online May 5, 2013 in Nature Genetics.
"This gives an unprecedented insight into the bacteria living and transmitting among us," said co-author William Hanage, associate professor of epidemiology at HSPH. "We can characterize these bugs to an almost unimaginable degree of detail, and in so doing understand better what helps them survive even in the presence of an effective vaccine."
Pneumococcal disease is caused by a type of bacteria called Streptococcus pneumoniae, which is present in many people's noses and throats and is spread by coughing, sneezing, or other contact with respiratory secretions. The circumstances that cause it to become pathogenic are not fully understood. Rates of pneumococcal diseasean infection that can lead to pneumonia, meningitis, and other illnessesdropped in young children following the introduction of a vaccine in 2000. However, strains of the bacteria that are not targeted by the vaccine rapidly increased and drug resistance appears to be on the rise.
The research, led by HSPH co-senior authors Hanage; Marc Lipsitch, professor of epidemiology; and Stephen Bentley, senior scientist at the Wellcome Trust Sanger Institute, aimed to better understand the bacterial population's response to vaccination. Whole genome sequencingwhich reveals the DNA code for each bacterial strain to an unprecedented level of detailwas used to study a sample of 616 pneumococci collected in Massachusetts communities from 2001 to 2007.
This study confirmed that the parts of the bacterial population targeted by the vaccine have almost disappeared, and, surprisingly, revealed that they have been replaced by pre-existing rare types of bacteria. The genetic composition of the new population is very similar to the original one, except for a few genes that were directly affected by the vaccine. This small genetic alteration appears to be responsible for the large reduction in the rates of pneumococcal disease.
"The widespread use of whole genome sequencing will allow better surveillance of bacterial populations even those that are genetically diverse and improve understanding of their evolution," said Lipsitch. "In this study, we were even able to see how quickly these bacteria transmit between different regions within Massachusetts and identify genes associated with bacteria in children of different ages."
"In the future, we will be able to monitor evolutionary changes in real-time. If we can more quickly and precisely trace the emergence of disease-causing bacteria, we may be able to better target interventions to limit the burden of disease," said Bentley.
###
Support for the study was provided by the National Institutes of Health, the Wellcome Trust, and the AXA Foundation.
"Population Genomics of Post-Vaccine Changes in Pneumococcal Epidemiology," Nicholas J. Croucher, Jonathan A. Finkelstein, Stephen I. Pelton, Patrick K. Mitchell, Grace M. Lee, Julian Parkhill, Stephen D. Bentley, William P. Hanage, Marc Lipsitch Nature Genetics, online May 5, 2013
Harvard School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory and the classroom to people's livesnot only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at HSPH teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America's first professional training program in public health.
The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programmes and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 5-May-2013 Share ] Contact: Todd Datz
tdatz@hsph.harvard.edu
617-432-8413
Harvard School of Public Health
Boston, MA A new study led by researchers from Harvard School of Public Health (HSPH) and the Wellcome Trust Sanger Institute in the UK has, for the first time, used genome sequencing technology to track the changes in a bacterial population following the introduction of a vaccine. The study follows how the population of pneumococcal bacteria changed following the introduction of the 'Prevnar' conjugate polysaccharide vaccine, which substantially reduced rates of pneumococcal disease across the U.S. The work demonstrates that the technology could be used in the future to monitor the effectiveness of vaccination or antibiotic use against different species of bacterial pathogens, and for characterizing new and emerging threats.
The study appears online May 5, 2013 in Nature Genetics.
"This gives an unprecedented insight into the bacteria living and transmitting among us," said co-author William Hanage, associate professor of epidemiology at HSPH. "We can characterize these bugs to an almost unimaginable degree of detail, and in so doing understand better what helps them survive even in the presence of an effective vaccine."
Pneumococcal disease is caused by a type of bacteria called Streptococcus pneumoniae, which is present in many people's noses and throats and is spread by coughing, sneezing, or other contact with respiratory secretions. The circumstances that cause it to become pathogenic are not fully understood. Rates of pneumococcal diseasean infection that can lead to pneumonia, meningitis, and other illnessesdropped in young children following the introduction of a vaccine in 2000. However, strains of the bacteria that are not targeted by the vaccine rapidly increased and drug resistance appears to be on the rise.
The research, led by HSPH co-senior authors Hanage; Marc Lipsitch, professor of epidemiology; and Stephen Bentley, senior scientist at the Wellcome Trust Sanger Institute, aimed to better understand the bacterial population's response to vaccination. Whole genome sequencingwhich reveals the DNA code for each bacterial strain to an unprecedented level of detailwas used to study a sample of 616 pneumococci collected in Massachusetts communities from 2001 to 2007.
This study confirmed that the parts of the bacterial population targeted by the vaccine have almost disappeared, and, surprisingly, revealed that they have been replaced by pre-existing rare types of bacteria. The genetic composition of the new population is very similar to the original one, except for a few genes that were directly affected by the vaccine. This small genetic alteration appears to be responsible for the large reduction in the rates of pneumococcal disease.
"The widespread use of whole genome sequencing will allow better surveillance of bacterial populations even those that are genetically diverse and improve understanding of their evolution," said Lipsitch. "In this study, we were even able to see how quickly these bacteria transmit between different regions within Massachusetts and identify genes associated with bacteria in children of different ages."
"In the future, we will be able to monitor evolutionary changes in real-time. If we can more quickly and precisely trace the emergence of disease-causing bacteria, we may be able to better target interventions to limit the burden of disease," said Bentley.
###
Support for the study was provided by the National Institutes of Health, the Wellcome Trust, and the AXA Foundation.
"Population Genomics of Post-Vaccine Changes in Pneumococcal Epidemiology," Nicholas J. Croucher, Jonathan A. Finkelstein, Stephen I. Pelton, Patrick K. Mitchell, Grace M. Lee, Julian Parkhill, Stephen D. Bentley, William P. Hanage, Marc Lipsitch Nature Genetics, online May 5, 2013
Harvard School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory and the classroom to people's livesnot only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at HSPH teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America's first professional training program in public health.
The Wellcome Trust Sanger Institute is one of the world's leading genome centres. Through its ability to conduct research at scale, it is able to engage in bold and long-term exploratory projects that are designed to influence and empower medical science globally. Institute research findings, generated through its own research programmes and through its leading role in international consortia, are being used to develop new diagnostics and treatments for human disease.
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-05/hsop-gsp050113.php
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CHALDOVAR, Kyrgyzstan (AP) ? An American military tanker refueling plane carrying three crew members crashed Friday in the rugged mountains of Kyrgyzstan, the Central Asian nation where the U.S. operates an air base key to the war in Afghanistan.
There was no immediate word on the fate of the crew. If any of them managed to eject from the KC-135 plane, the search for them would be complicated by the harsh terrain in the region.
The U.S. base in Kyrgyzstan, called the Transit Center at Manas, said it had no immediate information on the cause of the crash, but a resident of the agricultural and sheep-grazing area said the plane exploded in flight.
"I was working with my father in the field, and I heard an explosion. When I looked up at the sky I saw the fire. When it was falling, the plane split into three pieces," Sherikbek Turusbekov said.
The crash site is near Chaldovar, a village about 100 miles (160 kilometers) west of the base. Pieces of the plane, including its tail, lay in a grassy field bordered by mountains; the air was infused with the heavy stench of petrol.
The base, which is adjacent to the Manas International Airport outside the Kyrgyz capital of Bishkek, was established in late 2001 to support the international military campaign in Afghanistan. It functions as an interim point for troops going into or out of Afghanistan and as a home for the tanker planes that refuel warplanes in flight.
The base has been the subject of a contentious dispute between the United States and its host nation.
In 2009, the U.S. reached an agreement with the Kyrgyz government to use it in return for $60 million a year. But the lease runs out in June 2014, and the U.S. wants to keep it longer to aid in the withdrawal of troops from Afghanistan. Kyrgyzstan is reluctant to extend the lease.
On Monday, a Boeing 747 cargo plane crashed just after takeoff from the U.S. military base in Bagram, Afghanistan, killing all seven people aboard.
__
AP writers Jim Heintz in Moscow and Robert Burns in Washington, D.C. contributed to this report.
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ATHENS, Greece (AP) ? A lawmaker from Greece's extreme-right Golden Dawn party allegedly tried to punch the mayor of Athens on Thursday, swinging at him but reportedly missing and hitting a 12-year-old girl instead.
The confrontation came hours after police used pepper spray to prevent the nationalist party from distributing free food to Greek citizens only in the city's main Syntagma Square in defiance of a municipal ban the mayor had vowed to uphold.
Once a marginal group, Golden Dawn saw a meteoric rise in the polls in recent years, becoming Greece's third most popular party as the country slid further into financial crisis and unemployment skyrocketed. Its members have been repeatedly accused of involvement in violent attacks against immigrants and others.
"The only thing these people know is the language of violence," Mayor Giorgos Kaminis said after the incident, in which he said lawmaker Giorgos Germenis also tried to pull out a gun before being restrained by the mayor's bodyguards.
Germenis showed up at a municipal charity event where Kaminis was handing out gifts to children of unemployed parents ahead of Sunday's Orthodox Easter.
"This man sneaked in, we didn't notice him ... and he tried to hit me," Kaminis told Vima FM radio. "At the last minute my personal guards stopped him." The mayor said Germenis had a gun tucked into the back of his waist band, and attempted to pull the weapon out.
Television footage showed the mayor's bodyguards struggling with Germenis as a woman carrying a baby scurried out of the room. The security guards pinned the lawmaker against a wall before marching him out of the building.
Greek media said the blow intended for Kaminis ended up hitting a girl, leaving her with a bruised forehead but no serious injuries.
"Extreme actions, especially when their victims are innocent 12-year-old children, do not befit our democracy," said government spokesman Simos Kedikoglou.
Golden Dawn issued a statement denying a girl had been hit and vowing to sue Kaminis and his security guards. For his part, Kaminis intends to sue Germenis for the attempted attack, the municipality's press office said. Police said they were investigating complaints against the lawmaker for threats and brandishing a weapon.
Golden Dawn had announced it would hand out free Easter food to Greeks only on Thursday. Kaminis had banned any such events in the city's main square, and vowed Wednesday not to allow the "soup kitchen of hate" to take place.
But party members with Golden Dawn logo emblazoned across the backs of their black T-shirts arrived more than two hours before the announced time with a truck carrying meat, potatoes and other goods and began handing out bags of food after checking recipients' identity cards.
Scuffles broke out with riot police, who used pepper spray to repel party members wielding Greek flags on thick wooden sticks.
Giving up on the idea of a charity handout in the capital's main square, the party moved the distribution to its own offices in downtown Athens ? not far from where Kaminis later attended the separate municipal charity event.
"Today in Syntagma Square, the law was implemented against the Golden Dawn neo-Nazis who once again displayed their wares: racist hatred, the use of violence and bullying," said Fofi Gennimata, spokeswoman of the Socialist PASOK party that is a junior member of the governing coalition.
Though Golden Dawn rejects the neo-Nazi label, its website shows great fondness for Nazi literature and symbols.
Source: http://news.yahoo.com/greek-lawmaker-accused-trying-punch-mayor-161816271.html
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